I will try something and bet on the opposite of bookmakers favor in two of these matchups. One will be West Ham and the other one will be Roma.

Milan - Roma should already be considered as a really close matchup though. Unlike the gap between their championship odds I see them having near equal chance. Roma are much better as you have also mentioned. Milan are a really challenging opponent for them here maybe but this time they have a bigger chance with De Rossi.

Leverkusen are of course quite the favourite against West Ham on paper. However seeing them having big difficulties against Qarabag for some reason tells me to give West Ham a chance with a small bet. I'm doing this just for fun so let's see what happens.