It's a bit worrying about Manchester City's defense later and I think Arsenal will take advantage of Manchester City's weaknesses this time. The international break made the team structure quite chaotic and Manchester City cannot hope for much with the current options. But I'm pretty sure there won't be any problems as long as Pep Guardiola can provide the right strategic direction and I hope Arsenal won't be caught off guard just because they heard this news.
I don't think Manchester City lacks good players like that to guarantee Arsenal free penetration into City center back. They still have th likes of Ruben Dias and strong Midfield Rodri to protect their home. Remember this is Arsenal playing at Etihad and not the other way around, this is why I think Manchester City still have an advantage over Arsenal in this match. The international break has made some players unavailable but predicted lined up for Manchester City is solid in this match.
The match will be fierce and whoever scores the goal first will dominate the course of this match and as hosts Manchester City must do so. Mikel Arteta will probably not relax in the slightest and wants his team to play aggressively from the start. But you also need to remember that if a blunder occurs, it will make everything chaotic.
I will be happy if this match turn in favor of Arsenal, this match will help them stay above Liverpool and if they lose the match, more possibilities of Arsenal winning the league but it's not going to be an easy match this time around for the two teams. Manchester City want to win Arsenal to stay above, this is the only chance they have right now to give Liverpool a gap too.