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Manchester city as a team are very good and I know for sure that they don't rely on a single player before they perform their magic and that's why I feel even if debryune is going to be absent they can still manage their way out of the game and maneuver their way to victory against arsenal although the winning is extremely needed by the two teams so I don't know how the outcome of the game will be till they have played it out.
I have said, Manchester City will not depend on one player and their victory or defeat will not depend on one player either.
They have Bernardo Silva, Phil Foden, Jack Grealish, Jeremy Doku, Kovacic, Nunes as midfielders, while Erling Haaland is also ready for the match. Pep Guardiola doesn't have many shortcomings even without De Bruyne and Ederson, but if those two players are there then of course Pep Guardiola has many complete options in his squad.
Arsenal are not favorites, but they have a chance. Everyone also knows that Manchester City is the favorite, but considering that Arsenal has big ambitions to maintain the top position in the standings, the match will be very high-tension.