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This is a very difficult target, Madrid does have quality players and is ready to face Man City in better conditions. However, the problem is Pep Guardiola strategy often makes things difficult for Ancelotti. Ancelotti is a coach who has experience in the UCL, no doubt about him, but if he can't find the weakness in Guardiola's strategy, when you say that Madrid can win with a big score, I'm not sure about that. Even a 2-0 win is very difficult to achieve. IMO
Many people underestimate Manchester City because they only know that Real Madrid is the king of the Champions League with more titles. It seems as if Real Madrid can never be defeated and is invincible to any opponent, but in reality Real Madrid can also fail in many seasons.
The Real Madrid and Manchester City match is very difficult to predict. Both teams have great coaches and are very experienced in the Champions League, they also have players who are ready to give their best for their team. Real Madrid has a good midfielder, Manchester City has one too, and both teams have a good squad to beat each other. Both teams have a good mentality to face any team, so this match will be very difficult. People will support their respective teams regardless of the probability and superiority of the other team.
This is a fact that we can see from both teams, so I agree that the Madrid versus Man City match is difficult to predict. It's true that everyone will favorite their respective teams, but for bettors they seem to require a lot of consideration. It is difficult for us to find weaknesses in these two teams, and they also have the complete attributes to beat each other.
Home or away matches may not have a big impact on these two teams, they have a good mentality when under pressure. Madrid is a phenomenal team in the Champions League, their history and achievements will always be a motivation for other teams. But that won't make a difference, because the season has changed and they have to keep fighting hard to be able to do it again.
On the other hand, now the two teams are preparing to face each other in the quarter-finals, with just a few days left we will witness one of the best matches of the season. But speaking of preparation, Madrid has more time than City, this might affect their performance later.