This is a home match for AS Roma, so they can take advantage of this match to achieve a victory in order to widen their chances when competing in the second leg. Considering that their opponent is Leverkusen, Leverkusen is a team that is doing very well this season, this will not be an easy task for them. Leverkusen is also targeting champions in the Europa League, because they no longer have the burden of the Bundesliga, so they can focus more on matches in the Europa League.
If Leverkusen can win, then they will be more comfortable when playing in the second leg, because they will be playing in front of their own supporters, and we know that Leverkusen fans are very enthusiastic this season.
Playing as a home team may not provide a big advantage for Roma because their opponents this time have proven to never perform below expectations, in fact they can always get out of great pressure so they not only perform well in the Bundesliga but also in this European league.
The most impressive thing about Roma in the European league was when they reversed all predictions when they beat AC Milan, but overall Roma's performance is still not so stable compared to Bayer Leverkusen, because this team from Germany has never wasted the opportunity to continue maintaining its unbeaten record so far. In the Bundesliga, even though they have secured the title, they still play with high motivation to give resistance to their opponents, especially in the European league where Xabi Alonso has said this is their next target, my prediction is that Roma can only get a draw or if they succeed in winning it was only with a narrow score of 1-0.