The fee you pay for a transaction depends on number of inputs and ouputs, address(es) type, how congested the network is and how fast you want your transaction to be confirmed.
Take note that the fee doesn't depend on the amount of bitcoin you send.

The fee you pay for a transaction sending 50 BTC and including 1 input and 1 ouput would be smaller than the fee you pay for a transaction sending 0.001 BTC and including more inputs/ouptuts.