For the betterment of Atletico Madrid, Semione should be replaced with young manager with good coaching skills.
Considering how long he manages Atletico Madrid, some of their systems should be designed around Simeone so replacing him would take time. I wonder if the fans want that though. By fans, I mean those who travel and buy tickets to watch them play, not social media darlings who speak about "we are in a crisis" whenever their favorite team loses. Most of the time they're farming for views with their terrible analysis of a match.
Aiming for trophies is a good thing, especially if it's a CL trophy. The question is whether replacing a coach will magically answer that or not (probably not).