Winning in gambling will make your mood happy just as we get some rewards and we feel happy. These feelings are so great and we feel so energic and positive.
However, once we start to lose in gambling, we slowly move towards the sadness phase. If the loss continues and we keep on losing the money, eventually it can lead to depression.
It's a natural phenomenon, there's no body that doesn't rejoice or feel happy over their victory in any confronting situation. People usually feel happy when they are winning and sad when they are being defeated or if they have lose something they had expectations of winning. Repeatedly, I have mentioned that no body feels happy when they are losing money that they didn't plan to lose. In gambling, it wise to only stake the amount that you can afford to lose so that if the game get busted, you can easily let go of the sad mood.