In the midst of Manchester United situation of losing confidence but being required to start again next week against Southampton. It seems that a club like Southampton can also make Manchester United unable to score goals easily. For me, clubs at the lower level of the standings can sometimes be better than Manchester United's performance this season. Even if Manchester United gets 3 points, it doesn't seem too surprising, don't be surprised if Southampton is able to dominate the game 
Southampton does not seem to be in good form from my observation of their performance. Also, the way Manchester United is playing currently, I don't have much confidence in them. However, I have a little confidence that Manchester United will try to come out with three points in the match. But what I know is that the match may not be so easy for Manchester United to win, and that's why if I want to bet next week, I don't think I can stake on this game. I don't have much confidence in Manchester United anymore; their games are becoming unpredictable.
In Manchester United's last game against Liverpool, I bet on Manchester United to score a goal since it was their home game. But surprisingly, Manchester United was not able to score any goals. In fact, it was really worse as Liverpool defeated them 3-0. If Manchester United continues with this form, I can't say they will finish in the top four this season again. But let's see what happens as they come back from the midweek break; maybe their performance will improve.
Southampton just got promoted, and they haven't been that good in the Premier League so far. They play a low block, they try getting draws in difficult games. A 10-man Newcastle got away with a win. So... if this Southampton team gets a result against Manchester United, after an international break, things are gonna look bad. Real bad.
I believe Manchester United will use this break to get back on their feet and to try and come back in the league after 2 devastating matches against Brighton and Liverpool. Now this break should be of good use for them, as this can help them recover and fix all their mistakes. Also, Southampton's low block might just be a fun day at work for their talented wingers Garnacho and Amad. Their new number 9, Zirkzee is also gaining form, even though he wasn't that good against Liverpool, playing against an easier defense of FC So'ton might help him to get his scoring boots on!