If we look at it from this point of view, Bayer Leverkusen may have the highest rate of profitability.
Indeed. Unfortunately if someone applied the tactic, he already got 1 lose because Leverkusen failed to win in the second match. How if Leverkusen never played at their best level again this season? It will be a disaster if someone tries to rely on the tactic. Even in another league (ex: Serie A), there is no big team playing consistently. AC Milan and AS Roma are 2 examples of big teams but performed very badly in the early season. I just can't imagine if someone bets in these teams for the whole season. 
I think betting should be based on a week-by-week analysis of performances and a detailed analysis of the injury situation of the players.
Agree. We can't bet in a certain team without analyzing the condition of the players and their current performance/stats. We also need to know where the match to held, it sometimes also bring some influence for the possibility of the win. It is a quite complex matter, it is not as easy as in Slot. Betting in sports requires analysis.