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This is indeed a reasonable forecast, that PSG will be the dominant side in the game against Brest. PSG has a much stronger squad, and they are trended positive, while Brest will most likely have trouble to keep up their performances from last season, especially against a team like PSG.
On the other hand, even though PSG is more favored, in football, everything can happen. Likely Brest will play mostly defensive in this game and wait for a gap to counter after. In football, that can be a worthy strategy, waiting to counter: if it's performed right total defense – Sure it's hard, having full of stars attacking line like PSG. Of course, they are bulky and difficult to capture.
As for player rotation, it can be indicated that while Enrique might wish to maintain his key players fit for the Champions League match, PSG is likely to expose most of their main players in order to win. We’ll see how the match advances but with all those advantages that PSG has, it’s normal for many to make big-win predictions.
I am sure Enrique has measured the strength of his opponent's team, he will anticipate every possibility that could happen. especially when PSG is attacking, there will be a lot of open space in the Paris Saint-Germain area. however, Enrique will not let Brest have many opportunities, by giving tight pressing. plus, PSG will dominate possession of the ball more. inevitably, Brest will do long balls. this is just my speculation and scenario, besides we don't know for sure the line-up of both teams during the match later. so far PSG and Brest have applied the same pattern, namely 4-3-3. it could be, Brest will choose a different pattern so that his team does not concede many goals. related to the players, in order for their performance to be more solid, it seems that Enrique will continue to play his main players as starters. however, it is very likely that they will not be played fully. talking about the match after this, PSG will host Girona at their home, I will not speculate for the match between these two teams to compete in the Champions League. even so, PSG is more favored than one of the representatives from the Spanish League.