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In my opinion, there is no amount of pressure that will be on Manchester United coach and he will lose the match against Southampton. To me, losing the match against Southampton could be signing his sack letter. I trust that he understands this very well and he will work his way out to beat Southampton. Manchester United fans and management are even worried with the current position of Manchester United after playing some few matches. If any team wants to make the top four, it starts now and not in the 11th hour.
Honestly, Manchester United performance for the last two seasons has been very poor. Could you imagine that Manchester United wouldn't have been in the Europa League this season let alone to Champions League if not for the FA Cup they won. Judging by their performance this season, they might also not be in the Champions League next season.
If he loses the game against Southampton it may be the final straw the breaks the carmel's back. The club has been really patient with him, even after finishing 8th position last season, which is United worst ever finish in the top flight. They've been very supportive of him and have also brought in new addition to booster the squad. He has a talented team that can compete for major trophies and at the highest level. He has no excuse this time around than to do better.