The first week we are immediately presented with a big match where the English giants face the Italian giants

This could be a revenge mission for the final 2 seasons ago but on the other hand this could also repeat Inter's defeat that occurred in the previous final.
In that final two seasons ago, Inter Milan played very well and created many opportunities to equalize result. With big pressure from Inter Milan like that, if they equalize result, who knows what will be an ending for Manchester City.
Anyway, Manchester City seriously defended their slim advantage and succeed to win a first Champions League title in their club history in regret of Inter Milan. Will their coming match be a revenge for Inter Milan or Inter Milan actually consider this match as a revenge chance, I don't know.
A match between two giants is interesting for watching, it's all to expect.
But in the end they lost the final which happened 2 seasons ago and of course this is a good condition for revenge.
Currently the conditions are still the same where the squad has not changed much and their performance is also still very good in their respective domestic competitions, it's just that in this case of course playing home at Etihad and with a better probability than Inter, it is clear that Manchester City still has a good chance of getting 3 points in their first match.
But apart from all that we have to see whether in the end this first match they will immediately go all out for the struggle at the top of the standings or not because after all this is the beginning where the rotation of players must begin to be intensified with the tight schedule later.
Statistically Manchester City deserves to be the favorite in this match. They have a good record and probability in the Champions League, besides that they also play home which of course this will be very beneficial from a mental point of view. But of course we also cannot underestimate Inter's superiority in this match because after all we must be aware that Inter are also a big club and there could be a situation where this is not too favorable for Manchester City.
Manchester City are strong and already had feeling of winning Champions League but they're not unbeatable in Champions League. Inter Milan with their strength and experience in Champions League, can beat Manchester City in a direct clash. It will be a tough match for both and maybe they will satisfy with 1 point from this match.
I don't think Manchester City can't lose but for now I'm not sure Inter can do that but their biggest chance in this match is a draw because after all the difference in strength they are still superior to Manchester City although it cannot be denied that Inter is also one of the big clubs in Europe today.