If you look at the quality, the English Premier League has a quality above the Italian League and I think it is very reasonable if the bookies give Man City a greater chance of winning because Inter Milan will play away in this match so it is not easy for them to beat Manchester City who are in their best form, although surprises are still possible but getting a draw might be a fair result for both of them who look equally strong.
I find it a little difficult to determine predictions when it comes to top clubs when they meet, especially since it is still early in the season so we don't know their full performance in this Champions League even though we can also analyze through domestic league matches.
Undoubtedly, the Premier League is better than Serie A. But even in the last season we have seen Serie A teams perform well on the Champions League and Europa League platforms. So there is no chance of underestimating Serie A teams at the moment. Also the best club in Serie A is Inter Milan. And Inter Milan's squad is also very strong. Inter Milan players will play for the purpose of victory against Manchester City.
Manchester City won the match 1-0 against Inter Milan last season. Although Manchester City won the match, the performance of Inter Milan players was very good. So there is no doubt that the City vs Inter Milan match will be very competitive. As both teams are in good form I think both teams have equal chances to win. However, since the match is Manchester City's home match, bookih is probably considering Manchester City as the favorite. I will probably hold myself back from betting on this match.
Last season the Serie A teams did not play well in the Champions League, many Serie A representative clubs were eliminated when they reached the last 16 such as Napoli and Inter Milan, Napoli was defeated by Barcelona and Inter Milan was defeated by Atletico Madrid but for the Europa League competition the Serie A representative clubs performed impressively such as Atalanta who were able to defeat Liverpool and even won the Europa League title last season.
I am not underestimating the Italian League, it's just that if we compare and see the quality, the Premier League is still above them in any way so in my opinion a Serie A club that meets one of the Premier League clubs, especially a club like Manchester City, will be a big challenge for them even though Inter is the best club in Serie A.