Newcastle chances of securing full points are still open, and they do have the attributes to cause a surprise. However, without meaning to underestimate Newcastle, Manchester City remains the favorite team in the match week 6. Pep Guardiola has several rotation options to replace the injured Rodri, although the match has the potential to be troublesome for both teams, I don't think Manchester City will lose points.
But this will still be difficult and it will even be a surprise if Newcastle can beat City in this match. The 3-1 defeat to Fulham last week will definitely deal a heavy blow to Howe's men who could make this a slightly difficult situation where they struggle to generate confidence.
The advantage that Newcastle have at the moment is quite good where Manchester City will lose 2 of their vital players because Rodri is injured for a long time and KDB may still not be able to compete in this match, providing a little ease for the midfield even though Manchester City's dominance is still very strong but the midfield at least will not be as scary. The most important thing is that they have to make the most of playing at home because after all now they clearly have the advantage of fans in the match so this must be used as a spur if they want to take points in the match.