Even as Manchester City are facing some injury problems currently, some of their players won’t be playing some matches, so there is a slight decline in Manchester City's performance, but even with their current performance, Newcastle shouldn't be so difficult for Manchester City to win. I am expecting three points from Manchester City in the match, even if they won't be able to score so many goals in the match, but Manchester City can't afford to drop from their current first position, and if they can lose against Newcastle, then another club will take the position from them, so Manchester City won’t want to lose to a club like Newcastle.
I don't think that game will be an easy one for Manchester City. They will be without Rodri, De Bryune and Haaland. All these are very important players and they will all be missed. I believe if De Bruyne was available against Arsenal they would have won because they needed his long-range shot and accurate crosses in that game.
I am not sure if Haaland is injured but I saw updates earlier that he has a knock, if this is true then Manchester City are in trouble. They don't have any other striker since they sold Alvarez. Haaland is their most prolific goal scorer and playing without him might be difficult.
Newcastle is in good form, but they always concede so I expect the game to have at least 3 goals. Manchester United will also concede so both teams to score might be a good option to bet on.