Playing without two main midfielders Kevin De Bruyne and Rodri will have some negative impact on Man City's performance. Newcastle United can leverage these lapses and get a good result. Nathan Ake is another key player who is missing after he picked up an injury during international engagement. Kovacic and Lewis are a good replacement for both players and Gundogan and Stones could still fill the position. Newcastle also has some injury concerns like the toe injury of Alexander Isak. Matt Targett and Callum Wilson are also out due to health issues.
Pep Guardiola wouldn't want to lose any point after they lost two in Etihad against Arsenal. Newcastle has not lost just one game showing that they are not a club to look down on. Eddie Howe is also a good coach whose exploits in the EPL led Newcastle to qualify for the Champions League last season. It will be a good match to watch.
I don't think any football lover would want to miss the match between Newcastle and Manchester City because it's going to be very interesting. I've heard lots of rival fans saying that Manchester City could suffer their 1st lose in the league cause two important players from the Midfield area would not be available, I've would've supported that statement if Newcastles player Isak and other important ones that won't be present for them on the pitch were available but knowing that Newcastle still got important players left out for the game makes it fair and square for Manchester City. Anyways my support goes to Manchester City despite that they're the visiting team, I'll bet on them cause I'm pretty sure that Pep Guardiola still got good players that would fill in for Debruyne and Rodri, Kovasic and Gundogan would fit in well and deliver the job though the team would be lacking Rodri's defensive prowess.