Well, the match, namely the Newcastle vs Man City match, is like the main dish this week. Even though it is the opening match this week. I agree we can't possibly miss this match. And I am also quite confident in the quality of Man City who can still be expected to win this match even though they cannot play several of their important players such as De Bruyne and Rodri who have minor injuries and are still unable to play. Luckily this season Gundogan has returned to Man City. So when De Bruyne is absent, Man City will not have much influence there.
Kevin De Bruyne seems to have recovered from his injury and it is only a matter of time before he can return to the pitch but, making him a starter in the match against Newcastle is quite risky. It seems like a pretty good choice for Guardiola would be to play Gundogan, Kovacic, and Bernardo Silva as starters, and perhaps give De Bruyne some playing time in the second half.
Man City will most likely definitely aim for a win because previously they only got 1 point when playing against Arsenal. Even though Newcastle is not as strong as Arsenal but, they can be fierce when playing at home.