Rodri and Kevin De Bruyne being ruled out of City's games due to injury is really very sad especially for Rodri who could be out for a very long time until the end of the season as a result of how severe his knee injury he sustained in the match against Arsenal last sunday is, but that not withstanding Pep Guardiola can find suitable replacement from his squad and they move on so i don't see much threat to Manchester city in their upcoming match against Newcastle. I know Newcastle can be a stubborn opponent but Manchester city will try their possible best to record victory and still continue their campaign at the top of the league table.
At least Man City is always ready for this condition. That is why Man City always has very quality reserve players that Pep can use whenever the team needs them. Just like when De Bruyne suffered a long injury last season, we can see that this team is still able to stand strong and is difficult to beat by other teams in the Premier League except for Arsenal last season.
And yes, against Newcastle, I think it will still be a fierce match. Where Man City will still look strong and they will still be difficult to beat. Man City could even embarrass Newcastle in front of Newcastle's own supporters. But because I also don't want to underestimate Newcastle, I think the opposite could happen in this match. Where Man City will lose points for the first time.