Currently Barcelona is ranked 1st and Real Madrid is ranked 2nd in the standings. Both teams are in their best form and this makes me really looking forward to this season's el classico. They have a busy schedule and this will determine which coach can rotate players well before the el classico match. Real Madrid wants to get 1st place and Barcelona wants to increase the points difference from Madrid. This derby will be an important match for both teams so I think this game will be very exciting to watch.
Perhaps you have not watch the current state of Real Madrid but if they win their next two matches which one is in Laliga against Celta, they might win that one even with unregular players but you see Dortmund, they are seriously behind in many leagues and they also want to make ammendments but if Real Madrid put in their efforts, they will might survive that match but I don't know how they want to survive the El clasico due to their incomplete players.
Look at Barcelona last 5 matches, it's only Osasuna that fell out of their hands and that was from their own defenders mistakes. Osasuna has a long history of beating Barcelona in their homes and they did again this season and hence the reason for the last recent loss but now that Ansi Flick have improved on its defenders, I don't know if Real Madrid will be ready for their cooking.