If you prefer hardware wallet then definitely one wallet is enough, I don't think you need multiple wallets. Because every time you connect to your PC you might be instantly sharing (but never sharing) without your mind. And in case of any wallet you should keep your password very carefully, and when you open the wallet again you never use the old password and it will be most secure if you login with full keyboard.

And the whole role in keeping the wallet secure is yours, to keep the wallet safe you need to keep yourself safe then you can protect the wallet properly.