This is become a big loss for them in the middle premier and champions league.
I read his interview after the Spurs's game and he claims that this is the first time in his career that he has 13 healthy players available. Looks like the injury crisis is quite bad for City. On the other hand Arsenal and Liverpool also have some troubles with injury, although you could argue most of their key players are healthy for now. But who knows, City always perform well in the second half of the season so this time is crucial for Liverpool and Arsenal to gain as many points as possible to make sure they have a chance to win the league.
Most people thought that Manchester United might not be able to achieve in this match but it was their strong performance that really changed their game. Interim coach Ruud van Nistelrooy replaced Ten Hag with a brilliant strategy that led to Manchester United's impressive win.
I think this is quite common tbh. A new coach, new energy, etc. The problem is whether they can sustain that for long or not. At the end of the day, a new coach will come and the players must be prepared for that.