You seem to be referring to imbalances of single-seat districts, that's not quite the same (purposeful gerrymandering aside) as deliberate disenfranchising of certain groups of voters. Districts can get redrawn to make them more fair, and multi-seat systems exist that achieve better proportionality, but that has nothing to do with the arcane BS that is US electorate system.
Yes, surely my mentality is more focused on European electoral disproportions, where the difference in the weight of votes between regions is sometimes 1 to 0.9 or at most 1 to 0.5.