Some Real Madrid players who are injured will certainly affect their performance, even so they must have a replacement that is equally good in its contribution to balance their performance. With the injury of two of their players, namely Lucas Vazquez and Rodrygo, it is possible that Real Madrid could experience a decline, but the good news is that these two players did not suffer serious injuries so they are only absent for a short period of time. And it is true what you said, this is an opportunity for other players on the bench to prove their talent in front of their coach. In addition, they must be able to improve their performance, because their points are far behind their rivals, I am sure Ancelotti will do his best for his team to be able to catch up on their points.
The realization that they have a great offense but they have basically nobody left at the defense will hit them hard eventually. They can't keep fighting against the opponents with such a weak defense and there will be just a taking a bit of a time to see what's wrong at the moment. I believe this season is basically just gone, and we can't make it work, we are going to be forced to accept it as it is and we can't make it move any further. Life isn't fair and sometimes things do not go according to plan and this is one of those days, we are going to just suffer the reality and not really move any further at all.
I believe there will be moments when things aren't really clear and that means we are going to be forced to focus on what we have as reality. Real Madrid will have to realize that they can't be winners anymore, not with this many players missing, and eventually they will start losing again, and Barcelona will probably keep winning and get the title.