Facing Tottenham again won't be a problem to Pep Guardiola because he has already played them before and he lost but this time I believe he'll get something out of this encounter when the time comes. Losing 4 in a row is like becoming a big failure to Pep and he's going to re-write his mistake, I have that feeling that after the international break Manchester City won't be as slow as they have been and they will make the EPL a bit difficult for their opponents, their midfield won't be as weak as it were with the return of KDB it will be much better after the break.
I am not entirely sure if that would be the case, not easily at least. We have seen them lose 4 games in a row, I do not think that they had something like that during Peps tenure before, and I am pretty sure that fifth in a row is pretty unlikely so I would say they are the favourites to win this game. However, we also need to remember one of these games was against Tottenham as well, and Tottenham has a lot of players they are missing too, they just recently lost to Galatasaray because they lacked so many players.
So while I do agree that City is the favourites and they have what it takes to win, we are still not entirely sure what's going to happen, anything could happen in this game. If I were to make odds, I would probably put City at 1.70 or so, realistic, shows they are the favourites, but shows that it is not a guaranteed thing neither, it's definitely just a normal situation without much of a heavy domination assumption at all. Pep will care about this game more than anything, losing another would break the team.