De Bruyne's influence is very big for Man City, however, he is Man City's key playman, his absence plus several other top players also makes Man City's condition quite worse, coupled with the other row, Rodri. The injuries experienced by Man City players continue, fortunately at this time they do not occur simultaneously, so Pep should still be able to make the club stronger during their match in the EPL later.
He is a player who controls the rhythm of the game and at the same time a midfielder who always provides accurate passes to the striker so losing him must have a big impact on the attacks built by Manchester City.
The front line is quite crucial for Manchester City because they rely on ball possession so if the midfielder is not good enough at holding the ball then the tactics applied by Pep Guardiola will not work perfectly.
That is the reason why Manchester City has not gotten good results in the last few matches because there are no players who are able to control the game in midfield.