Liverpool won't be tired more than City, they will both be tired considering how many injuries each team has and how many games they play, things aren't that easy and because of this we need to consider how to get better results on the long run as well. Fatigue is the biggest reason for injuries, I just hope that we do not see players get injured in this game, not all injuries are results of tackles, most of the injuries are done when someone tries something very normal, nothing out of ordinary, just because they tired themselves out too much.
Hopefully, with this situation being so tiresome, we could finally see UEFA and whatever else competition organizations out there, they can see it's ruining football to have this many games, it means more money when you have more games but it also means that you are tiring the players out a lot more and injuring them and that means we actually watch them less now, back in the day there were less games but players were injured less and we would watch them play more games in total.
Liverpool have the advantage in this match, they have the squad depth to rotate players effectively and maintain their competitiveness. Manchester City players complained about the number of games they have to play because of the new Champions League format. I think the players are not ready mentally and physically for the busy calendar, it’s no surprise that they are fatigue and are sustaining injuries. I think the number of fixtures should be reduced from next season so the players w can be fit and maintain the quality of the game.