Even though Manchester teams aren't very well these days and very inconsistent but I still think that Manchester United might manage to collect 3 points in this game. Viktoria Plzen is not that bad but not that superior to Manchester United.
In this round, the other games look not that obvious and Ajax - Lazio looks good to follow regarding the performance of these teams in their corresponding league.
Looking at them in the Europa League standings this season, they have no difference, even in terms of points they have the same points. I agree that Viktoria Pizen is not that bad, but when compared to Manchester United, they are also not better than Manchester United, so I personally believe that Manchester United should be able to win this match, of course it is not easy to do all that. Amorim will also definitely try his best, considering that he has not found the right composition with what he wants to implement with Manchester United. However, with some of their capital in the previous match, I think he has started to find a strategy that can make his team better.