On paper, Man United are indeed favorites to win the match against Viktoria Plzen. We know that Man United are still experiencing ups and downs in performance in the Premier League, but in the Europa League, Amorim squad has not been touched by defeat. The Europa League offers a greater opportunity for The Red Devils, this is an easier path to get a ticket to the Champions League next season. Amorim arrival has certainly increased fan expectations, and it is not easy to achieve the desired target. Amorim is determined to reach the round of 16 automatically, losing points will require them to take the play-off path. On the other hand, this match will be valuable capital to travel to the Etihad in the Manchester derby, clearly Amorim must work harder to prepare his team well.
Many will take the betting option that Manchester United will win in the continuation of the UEFA Europa League, but I think like you that on paper Manchester United can still be relied on because Manchester United is a famous team that plays in a famous league, while their opponents are not followed like they follow Manchester United.
Behind that, I have a feeling that Manchester United will not easily win as favored because this match is not taking place in England but in the Czech Republic.