i m not quite sure what you mean by "trade against"
Simply trading-pairs, what market-pairs does a given thing offer.
Many exchanges offer BTC/whatever for a whole lot of whatevers, also useful us having several exchanges for selling a particular thing for fiat.
Part of why BTC and XLM are useful is a lot of fiat-exchanges, that is, places one can sell crypto for fiat (and usually also buy if for fiat but that is a direction I never go in since my income is crypto so I only sell it for fiat never buy it with fiat).
BTC and XLM are especially useful because not only can I buy and sell almost any other crypto with BITC or with XLM or even with both but also both are so easy to cash out to fiat, so they are gateways funnels or channels whereby pretty much all other cryptos can be cashed out through toward fiat.
-MarkM-