When the opposition is very tough and when it is likely to be a close match, betting on such matches should always be avoided because either team can win the match and the result can be a draw at any time. Betting should be done in such a way that the side I am betting on has a higher chance of winning than the opponent. Apart from the match between Liverpool and Tottenham in the Premier League, there are many other matches where it would be easier for a gambler to bet on the opponent. I think gamblers should look forward to that opportunity. Maybe there is a little less amount of profit to bet on such matches but I think it is better to have a lower profit than a higher risk of losing money and I always prefer to gamble with this strategy.
Liverpool and Tottenham are not too big in quality difference and in only one match, difference from Liverpool good performances since the season starts can become nothing, if Tottenham can play with their best capacity.
Tottenham have all necessary good players to beat all clubs in Premier League, not only Liverpool. Their biggest problem is unstability in performances and it makes any prediction on their performance and result in this big crash with Liverpool is very difficult and unpredictable. Tottenham can win or can lose to Liverpool, but I see their chance to win isn't actually low.
Liverpool of course with their better performances in the league so far, have higher chance to win this match, but they must be careful with Tottenham, that is not an easy opponent and won't let Liverpool getting 3 points too easily.