You mean making profits or taking profits? I know that some people struggle on taking them after making profits, and get to be a bag holder, but imho it's pretty straight forward.

First you take out what you put in. Leave the profits, and then slowly start to cash out like inverse DCA. And after a while, you either leave some small moonbag that you forget and check on later on next bullrun in >4 years maybe, or if you are planning to exit completely. Never check how token that you got rid of is doing later on, because nothing good can come from that. Either you get peace when you see that token has died, or it mooned and you will be kicking yourself. There's no upside of knowing that.