Real Madrid vs RB Salzburg on 22nd January at Bernabéu mean things could be well favourable for them and having easy win because Salzburg is currently in the worst situation due to their poor run in six games they have only one win against Feyenoord and their chances for top 24 almost ended now they are playing their remaining matches just for filling things with Real Madrid after this win could be in top 15 which mean chances are high for them to have spot into playoffs for next round which could be also not bad.
Brest is surely surprise package into this season with their performance in Champions League currently they are in top 8 and their next game is against Shakhtar Donetsk which is another worst team in this season and Brest can handle them for having their spot into top 8 but surely last game which is going to play in France could be interesting, but Real Madrid know how to have win and go through for next round.
This game seems good for Real Madrid. Salzburg is not doing well right now having only won one game out of six which makes it hard for them to be in top 24. If Real Madrid wins they might move into top 15 which would help them get spot in playoffs for next round. At same time Brest is doing better than expected this season and is currently in top 8. Their next game against Shakhtar Donetsk another team that not doing well is chance for Brest to keep doing well. But Real Madrid has a lot of experience and skill which will probably help them win and move on to next round.