You're thinking process is not as safe as you think it is, it can be attacked, by for example making you panick somehow, interesting isn't it ! 
Good luck with that. Quote
For example:
An exchange just announced it's closing up shop soon, and you have lots of different coins on it
Right. If your best example is the completely unrealistic scenario in which I keep lots of money on an exchange, there's no point discussing this. I like my Bitcoin transactions to be immutable.An exchange just announced it's closing up shop soon, and you have lots of different coins on it
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Just one little example of how somebody could "press your buttons".
They don't call me Switzerland because you can "press my buttons".Quote
Maybe you can think of something that makes you panick, recent panicks might be the recent fires in L.A. where people lost their homes, perhaps sleep deprived from all the stress, fleeing for their lives, not sure if their brains would still function properly after all of that, and they try and buy something with bitcoin...
Sure. Your house is on fire and you need to pay the private fire brigade with Bitcoin. Now you have to wait for 5 confirmations before they know you can't replace it anymore, and another 6 confirmations so they're sure no miner would Fork away 6 blocks on top of that. Your house is gone now.