Would it have been possible to buy 1000 usd of bitcoin in 2010 or earlier? If not then how to acquire this amount or more?
Yes that is very possible, you can even mine it around that time as well and have a lot of Bitcoin in you. However, we can't turn back the clock, and even if we have heard Bitcoin before, majority might not be interested on it in the beginning.
Right now if you wanted to acquire it then it's obvious that you need to have a lot of money to invest. Think of it as like Michael Saylor is doing, but majority of us doesn't have millions upon millions to invest and acquire a lot of Bitcoin. But you can still start your journey and still invest in which ever way you can.