It both loss of money and collateral damage for my perspective 

What's the difference between gambling addiction from casinos and loot boxes?

If you are addicted to buying a loot boxes and want to find the Item do you want then congratulation you are just same as addicted to gambling hahah this is purely my opinion tho But hey Buy a loot boxes with real money it just like you play a lost the only different here is you win a game item in the loot boxes and you win the money in a slot.

But if you buy the loot game with fake money or in game money then I would say I don't consider that as gambling