In view of the appointments of Rome who have all been positive I would say that they can now aim for the victory and the passage of the turn the shape of Ranieri's Sqaudra, it can truly give excellent hopes to pass the turn against Bilbao Roma is not among the favorites to Success of the tournament, in fact just behind Lazio there would be Atletico Bilbao.
Bilbao did play well during the qualifying round. They got positive results from 8 matches with 6 wins, 1 draw, and 1 loss. In La Liga Bilbao also performed well, now in the top 4 with tight competition.
Facing Roma, of course, is not an easy opponent. The Roma vs Bilbao match will be interesting and very tight. The first leg will take place at Roma's home ground, they play well at home and I think they will get the advantage.
In La Liga, Bilbao also played well and now they are also in 4th place in the La Liga standings. While AS Roma is still as usual, they are in the middle of the standings.
In the European League it is the same, Bilbao was able to finish in 2nd place in the league round while AS Roma were far below and they had to go through the play-off round first, fortunately they were able to finish it well so now they can be in the last 16.
In my opinion, AS Roma's chances are not greater than Bilbao's, but they can still win as long as they have to perform well in 2 matches.