In view of the appointments of Rome who have all been positive I would say that they can now aim for the victory and the passage of the turn the shape of Ranieri's Sqaudra, it can truly give excellent hopes to pass the turn against Bilbao Roma is not among the favorites to Success of the tournament, in fact just behind Lazio there would be Atletico Bilbao.
Roma is in the best condition in the last 3 matches across competitions, but that does not mean that Ranieri's squad will be able to be stable in each match. Against Bilbao is not easy, especially since this team from the Spanish League is quite competitive. However, Roma can rely on the home game in the first leg, the target is to defeat Bilbao with a landslide score. If they succeed, then in the second leg Roma can play with a full defense system. On the other hand, Atletico Bilbao is not an easy team to defeat. Moreover, this team is advancing with good performance in the Europa League, becoming runner-up under Lazio during the group stage. I am quite sure Bilbao is also targeting to win the trophy in this competition, with the existing squad they should be able to make it happen. However, it all depends on the consistency of the Atletico Bilbao players themselves, plus a very challenging job for Ernesto as the architect of the Atletico Bilbao squad. For this match, I prefer Bilbao to win the match in the first leg even though it is an away match.
3 matches is a start, but it's not strong evidence for Roma being in their best condition. They still have those very well known weak spots. There is an uptrend though and it certainly doesn't hurt them to have gained confidence from the last view games in all competitions and to be unbeaten for quite some time in the Serie A. But they are still 9th only. However, there have been teams in the past doing very badly in their league and then still play very well in the Europa League.
But they aren't really my favorite just yet as I think there are some teams that are more stable and play better football. Athletic Bilbao is one of them. But it will depend on when these teams meet and while small advantages may be found for one team or another, most of them are quite equal.