They will face Real Sociedad in Spain and the first match will be difficult away. Also, Real Sociedad, who they will face, is one of the strong teams in Spain. They are strong enough to beat Manchester United, who are not in form. Therefore, if they want to advance to the next round, Manchester United should not lose in Spain. They can win the match in England, but their job is really difficult in Spain.
Real Sociedad have always been a team that often causes problems for the big teams in La Liga, the last defeat to Barcelona was because they played with 10 men from the 17th minute, overall their performance was not as disappointing as Man United. In my opinion, the only big problem that Man United have is playing at Sociedad's home ground, it is very difficult to beat Sociedad when playing at their home ground, so the final result is clear who will win and who will lose.
The odds available at the moment, at least Real Sociedad is still quite favored although indeed, it seems it will be difficult for Manchester United to get a good result in the away game in the first leg later. But even so, there will be two legs that Manchester United will probably make a good effort to get a draw in the first leg, and then will target a win at Old Trafford for the second leg later. But indeed, the scenario of losing and winning will certainly happen and Amorim should be able to maximize the match in the Europa League after getting a series of bad results in the domestic league.