Even though there's no permanent transfer agreement after the loan period ends, Real Betis could make an offer when the summer transfer window opens. However, it seems Real Betis will have difficulty making Antony status permanent, because Manchester United is reportedly asking for too high a price. Manchester United wants to get at least half of the fee they spent when recruiting Antony from Ajax, which of course will strain Real Betis finances.
Sure, Real Betis will have a chance to sign Antony in the next transfer window. They can give an offer but it is true that Man United asks a quite high price. However, Real Betis can negotiate with man United management. It shouldn't be so difficult to release Antony because he doesn't get a place in Man United team. Man United looks like to have no intention to bring him back to their squad.
In my opinion, the Premier League is too competitive for Antony. In La Liga, he was able to adapt quickly, and it can be said that he is starting to rediscover his best form. Therefore, leaving Manchester United seems to be a better option next season. Besides that, Ruben Amorim seems he would not mind releasing Antony permanently.
No, Antony has no problem with EPL, he has a problem with Man United.