The second leg of Real Madrid vs Atlético Madrid is definitely difficult to predict as the odds are not very wide. The odds of the two teams are close, but the bookies have tipped Real Madrid to win. Since this match is at Madrid's home ground, they will enjoy the advantage and will be strong in defense and attack. Every match in the Champions League is very difficult, but I think Real Madrid have a lot of experience as they have won the UCL many times. And for Atlético Madrid, Ancelotti will definitely try to adopt a different strategy and build a strong team to enter the quarter-finals.
Real Madrid and Atletico Madrid are the top teams in the La Liga and they will be facing another challenge yet again to see who gets to qualify for the Champions league quarterfinals. Real Madrid have an edge over them but I am sure this match will still be a tough one as only one goal difference is not enough for Real Madrid to host of confidence in their first leg games and have an upper hand in their second leg game to win. The champions league is indeed a game of the champions, both teams have experience in the champions league but Real Madrid have won and excel in the competition more than Atletico Madrid does, so technically the odds will favour Real Madrid but Atletico Madrid will have a chance if they play well and get to prevail in the match.