There are good scenarios that an investor can take loan and Buy Bitcoin, one is, if he has an alternative and consistent source of income that he or she isn't going to rely on the profit that would come out of his Bitcoin investment portfolio to pay back his loan, this way if one sees opportunities in the market to buy Bitcoin for long periods of when he or she doesn't have that amount of money instantaneously, taking loan can be good, whereas on the other hand, I do not advise taking a loan with the hope of paying with the yields, you may get disappointed in end.
But in my personal opinion what I think about investing by taking loan even in bitcoin is not a wise idea rather than I will say it wrong move.
No matter how good a professional analyst a person is, he can never avoid some risk factors. Which often depend on luck. Then there are some things like wallet hacking, which can put you in big danger if you go for investment with a loan. I have also seen people giving status who have been holding Bitcoin for 10 years and lost all their funds due to phishing when their wallet was hacked.
So I think it doesn't matter how you have the skill or knowledge you should be always take that much risk what you can afford to lose.