That's my plan... I'll hope for the best, but I won't be surprised or disappointed if United doesn't make it to the semi-finals.

United has what it takes to reach the semi-finals, but they need to be careful, Lyon will not be easy to beat!
Lyon has the talent and tactical discipline to cause United problems, especially if they can exploit defensive weaknesses. If they can stay compact, counter-attack, and take their chances, they have a chance to pull off a statement win
Whatever happens, the match between Manchester United and Lyon is going to be a spectacular clash. IMO
Manchester United desperately needs to win this competition if they want to play in any European competition. From the look of this they might not make it to the top five, which disqualifies them from any continental competition. The English Premier League has more quality than League One, and the Red Devils also have quality players, which makes them the favourites. But their inconsistency this season makes me cautious while betting on them.
Lyon is not doing badly in the French League. They are occupying the fifth position, which means they will still play in the Europa League next season if the League ends this way. I expect them to give Manchester United a good fight and they might even qualify if they work hard.