Unbeaten in the Europa League might be a consideration for betting but the consideration might be a draw. Both teams will fight harder in the first leg because maybe this is a chance they can get in the second leg. If one of them is able to take advantage of the first leg to get a win then the chances in the second leg will be quite potential to win the match again.
I rarely bet on Manchester United because this team is difficult to predict and it is too difficult to maintain the performance of the game especially in the Premier League, but if you look at Sevilla's history in the Europa League maybe Manchester United has almost the same.
I rarely bet, betting i don't think i would bet on Manchester United because they are difficult to predict and have played really badly in recent years, but Sevilla's history in the Europa League could make you think that Manchester United have a similar chance.
Although i don't think so.