With the two major leagues standing, the fight mostly goes between Barcelona and Real Madrid. Real Madrid as the main focus Barcelona are quite on the safe space where they have to only maintain their position, Madrid are the one's suffering to make the top of the table, faced with a serious games in the Champions league and having to deal with Barcelona who are not minding still confiscating the top position among Real Madrid or even Atletico Madrid who were once seen as a fellow contender.
Yes of course the league race is obvious for the two teams that you mentioned, I just hope Barcelona maintain their winning streak, the only thing that can deprive them of the league is not being consistent though the points difference between them Real Madrid is not much that's why they should be more consistent this time, it wouldn't be nice for them to get on any lapses as did after toping the league at the begining of the season, Athletico Madrid is out from the race as I see unless there's a change in their own side or Barcelona and Realmadrid will create an avenue for them aside that there's nothing they can do as it stands.
Though Real Madrid is a good team with experience that's why no one should joke with them, even as they will be having a serious match in the champions league, they can't be underestimated.