Quantum computers? Bugs in the code? Centralized mining?
IIRC, quantum computing can only bring 256-bit bitcoin private key to be "as safe as" 128-bit.
There are many different wallet clients out there, and people are using different versions. Bugs in the code may affect some people, but probably not for the majority.
I think centralized mining could be a big problem, especially if we have some "bad" big miners trying to double-spend their own transactions.