Maintaining consistency is very difficult and that is still a problem that Amorim has not been able to overcome so when facing Lyon they must be able to provide something much better than before. Rayan Cherki's quality has indeed increased over time and he needs the support of his teammates because without that support he cannot do anything.
This will be a difficult match for both because currently both teams' performances have not been very consistent throughout the season. The role of the coach is quite decisive in one of the steps in achieving victory in the match because they have to see the weaknesses of one of them to exploit.
Amorim will have a difficult time maintaining consistency with their available player. The manager showed his knowledge and experience, if another manager had been in charge, I am confident they would not qualified for the Europa League quarterfinals this season. Having injured players does not prevent a team from winning games, it all depends on the manager's strength, and Amorim has proved that he is the right manager to take this squad to the next level.
However, if we look at the positions of both clubs in their respective leagues, I believe many people would choose Lyon to beat Manchester United because Lyon is fifth in the standings and Manchester United is 13th. Manchester United may defeat Lyon to advance to the next round if they perform at the level of their previous two games; Lyon might not even be as tough as we believe they are going to be against Manchester United.