Barcelona shouldn't mess up with this opportunity, because it's their only chance to make a difference in the point gap for them to be in a better place of winning the league. Madrid is not going to give up on the title race until the end of the season which makes it dangerous for Barcelona to relent in any of their upcoming matches. Osasuna should be an obstacle to them.
Barcelona must win this match to get 3 points, this will make the difference between them and Real more comfortable, Barcelona should approach this match responsibly, so as not to lose points in a home match against a weaker opponent. Real is close, that is why they need to do everything possible to break away from them, in the remaining matches this may come in handy. Atletico seems to be already out of the championship race.