After the international break, Barcelona will play 2 matches this week. I think that's a big deal for Flick. Many Barcelona players play for the country. I think there is a considerable fatigue.
But in other positions, Osasuna is also not in the best condition. Osasuan is winless in the last five matches in La Liga (three draws and two losses). It's hard to predict, but if Barcelona are all in good shape, then I'm sure Barcelona can win. Barcelona must be able to get 3 points, so that they are more comfortable in 1st place and have a difference of 3 points with Madrid.
Only both Raphinha and Araujo who absent due to international duty.
Looking at their formation, they will play serious because they use senior squad, unlike their previous match where Barcelona mix their lineup with young players. This should be an easy match for Barcelona, Osasuna is no longer an underdog, their performance fall down now.