In their last league match, Barcelona lost 4-2 to Osasuna. At that time, no one saw Osasuna as a favorite, but they won the match with a clear advantage. This match could be a rematch of the first match for Barcelona. Although Osasuna played exceptionally in the first match, I think their chances of winning this match are low.
Osasuna was the underdog, yet still they won the match. However, I don't think that will ever happen again as the saying goes "once bitten, twice shy". Osasuna is unlikely to upset Barcelona again, especially since the math will be played at Barcelona's home ground. And also considering the league standings, where Barcelona, Real Madrid, and Atletico Madrid are in a tight race with just four points separating them, a loss to Osasuna seems highly unrealistic. Given their home advantage and the stakes involved, Barcelona will likely secure a win.